Personalized mammography screening has emerged as the way of the future for improving breast cancer screening effectiveness. In order for individualized screening to be applicable in a clinical setting, one must first improve methods of evaluating individual risk by validating risk factors. Breast density, a measure of the dense tissue in the breast, has the potential to be used as a strong predictor for breast cancer risk. Strong evidence relating breast density and cancer risk has been established for 2-dimensional methods of estimating breast density, even with the subjective nature of that process. Considering that the breast is a 3-dimensional structure, efforts were made to develop methods to assess volumetric breast density (VBD). With the implementation of digital mammography in B.C., the quantitative analysis of mammograms to estimate VBD is now available. However, validation data to support the direct correlation of VBD to breast cancer risk for an ethnically diverse population like British Columbia is not available. 

This study proposes to establish the direct link between VBD and breast cancer risk for women in British Columbia. Once substantiated, VBD, together with other risk factor information, will be necessary for the screening mammography program to develop effective personalized breast screening strategies such as ultrasound screening for women with dense breasts. Therefore the results of this study may have the potential to change the paradigm of early breast cancer detection from a uniform-screening method toward an individualized, risk/benefit based personal approach.